2020 PDA Annual Meeting - Parenteral Drug Association (PDA)
Celebrity PDA of 2019 Gallery Wonderwall.com
Haddad was the chair of the Paradigm Change in Manufacturing (PCMO) initiative: QRM in Packaging and Labeling, QRM for the Design, Qualification, and Operation of Manufacturing Systems task forces, co-chaired the Aging Facilities Points to Consider and co-chaired the 2018 and 2019 Annual PDA Conferences and the 2019 PDA Quality Week. 2019 Conference Follow-up About Us. Beginning in 2000 the Polyurea Development Association (later shortened to PDA) was the trade association that represented polyurea technology. Its volunteers worked tirelessly to help explain, train and promote this amazing technology. In the ensuing years, PDA has expanded its reach to include thick-film ... Patent ductus arteriosus (PDA) is a very common finding in extremely preterm infants less than 29 weeks of gestation. Persistent patency of the ductus arteriosus in preterm infants is unequivocally associated with increased morbidity and mortality. ... (2019). Crossref. Jalal M. Abu-Shaweesh, Eyad Almidani, PDA: Does it matter?, International ... The 2019 PDA Rapid Microbiological Methods Workshop will provide attendees with an overview of the current landscape for rapid method validation strategies, implementation opportunities, and global regulatory approval processes. Presentations by subject matter experts and global regulators will focus on real-world practices for rapid and ... Celebrity PDA of 2019. Share Tweet Pin Email. By Wonderwall.com Editors 6:00am PST, Dec 10, 2019. Wonderwall.com has rounded up the best (and cutest!) celebrity PDA moments of 2019! Let's begin ... pda 2019 – understanding sterilization Fedegari is proud to collaborate with PDA Europe hosting the hands-on training course “Understanding Sterilization” on 26-28 th February, 2019. The course will be held at Fedegari’s Tech Center, where participants will be able to discuss real-life problems while using Fedegari equipment to apply ... 2019 At A Glance; 2019 At A Glance. The 2019 At A Glance handout is a brief (1 page front and back) overview of our work in 2019. For a more in-depth look at our work, check out Mission Mosaic. (front) (back) Download the PDF (7.0 MB)
Nie, to nie „ten sam" koronawirus
2020.10.19 11:53 Colonel_PingPongNie, to nie „ten sam" koronawirus
Tekst autorstwa Piotra Gąsiorowskiego, znaleziony na grupie "Teoretycznie tak - grupa pronaukowa". Cytowano tu wywiad z prof. Kuną, pulmonologiem i alergologiem . W wywiadzie prof. Kuna mówi tak:
Powiem wprost: w podręczniku chorób zakaźnych, który mam z lat 70., czyli z czasów, kiedy byłem studentem medycyny - 50 lat temu, opisywano dokładnie tę samą chorobę i te same koronawirusy. Nic się przez 50 lat w tej kwestii nie zmieniło. Tylko, kto pamięta, co było w podręcznikach sprzed 50 lat?
Ponieważ „antykowidowcy” natychmiast podchwycili tę wypowiedź i powtarzają ją szeroko w internecie, uważam, że warto ją sprostować. SARS-CoV-2 jest całkiem nowym gatunkiem wirusa. Pierwsze znane przypadki infekcji u ludzi pochodzą z listopada lub grudnia 2019 r. Być może istniał wcześniej w jakimś rezerwuarze naturalnym, ale nie można tego stwierdzić na pewno przy obecnym stanie wiedzy (mógł powstać np. przez rekombinację przy zakażeniu człowieka dwoma blisko spokrewnionymi wirusami odzwierzęcymi).Oczywiście SARS-CoV-2 należy do znanego od dawna kladu wirusów (Orthocoronavirinae), wywodzącego się od wspólnego przodka. Klad ten obejmuje ok. 40 dotąd odkrytych gatunków, z których tylko 7 zakaża ludzi. Do tych ostatnich należą m.in. SARS-CoV-1 i MERS-CoV, wirusy groźne, ale szerzące się mniej skutecznie niż SARS-CoV-2. Powodowały one w przeszłości epidemie ograniczone geograficznie: po kilka tysięcy przypadków i kilkaset zgonów. Na przykład MERS nie stanowił zagrożenia globalnego, bo wirusem zarazić się można było głównie od wielbłądów (ryzyko przenoszenia go między ludźmi było niewielkie). Epidemia ograniczona była zatem do Półwyspu Arabskiego. Pozostałe koronawirusy infekują różne gatunki ssaków (alfa- i betakoronawirusy) i ptaków, (gamma- i deltakoronawirusy), ale nie ludzi. Nazwę koronawirus dla przedstawicieli tej grupy wprowadzono oficjalnie w roku 1971 i tylko w tym sensie prof. Kuna nie mija się z prawdą. Od wczesnych lat sześćdziesiątych wiadomo było, że niektóre koronawirusy infekują ludzi (stosunkowo niegroźnie), ale nie były to „ta sama choroba i te same koronawirusy”. Tu pan profesor po prostu dezinformuje albo mówiąc wprost, kłamie, bo nie wierzę, żeby jako profesor nauk medycznych nie zdawał sobie sprawy z różnicy. Koronawirusy zwierzęce identyfikowano od lat trzydziestych, choć nie istniała jeszcze ich zbiorowa nazwa, pochodząca od widocznej pod mikroskopem elektronowym charakterystycznej otoczki wypustek. Jednak ostatni wspólny przodek dzisiejszych gatunków wyewoluował być może już w mezozoiku, co oznaczałoby, że koronawirusy koewoluowały z nietoperzami i ptakami od samego początku istnienia tych grup na Ziemi .Nie oznacza to bynajmniej, że SARS-CoV-2 to „nic nowego”. Żaden z dotychczas znanych koronawirusów nie zainfekował w ciągu 10 miesięcy 40 milionów ludzi na wszystkich kontynentach i nie spowodował 1,1 mln zgonów. #koronawirusy#COVID19#wirusologia#medycyna#pandemia#ewolucja#debunking  https://polskatimes.pl/prof-kuna.../ac15-15222604  https://pubmed.ncbi.nlm.nih.gov/23596293/
2020.10.13 13:56 FeiendlyFace20Found Husband had used hookup apps solely for gay men for years - I’m a woman and we’re married but together 6 years altogether. Shocked!
And we we’re trying for babies, before this! My world was turned upside down seeing my husbands history of Grind snapchat/ Skype etc installed and uninstalled over years. All at various hours a lot in the early morning/ late at night but a lot while he and I were in work, when I’d be asleep , when I was around, in our home in our bed! The love of my life who proposed to me and I adored unconditionally - I felt so blessed that he wanted to marry me he is my dream man, no box left unticked! Or so I thought. Handsome, intelligent, professional, well rounded person, warm when he wanted to be and cold at times but he always had an excuse ALWAYS! The type of person that’s friendly to everyone so no wonder everyone loves him including my family! He came across as the most genuine man I’d ever met. Myself, my family & friends all love him and think were the best couple! Little do they know, and me too until recently! But there was a niggling feelings that just something was off, nothing to point to anything just feeling like I wasn’t enough. At various times i’d let my gut feelings slide about little things, thinking I was just insecure and he’d tell me that a lot and and at times say I’m “needy” for wanting to discuss something like why he needed to be asked to show me affection. Although the sex and erections were never a problem! Fantastic in fact - and it kills me to say that but it’s true! And has confused me more as I’ve read many women who say they had separate beds or no sex or erection issues - our marriage did not fit those categories; we shared our bed every night, sex most nights. I’d say minimum 5 times a week if I had to estimate; that’s for the last 6 years basically. I would ask him was he ok as he seemed off a lot, but he told me “I’m standoffish sometimes” and “I don’t like PDA”. Me not wanting to trigger more upset for him by arguments, I’d say nothing a lot of the time and bend to do things his way. As I thought these were the “don’t sweat the small stuff” stuff, that you’ll hear from any married person. I wanted and tried to believe that, until I couldn’t anymore. Looking back I really had no regard for myself and instead of challenging him as when I would try he would lose it and tell me to leave as he couldn’t change. I loved him so I didn’t leave him, I’d self medicate to feel better going to personal therapy, although I had not put my finger on anything until this year after our anniversary weekend away. Which turned into a nightmare! I always believed I was the problem as my parents separated, and have issues like we all do and I feared I internalised these issues and projected them so have always tried tonne reflective and understanding. His family seemed so perfect and healthy - until that wasn’t the case very long story! But back to him - through me searching I found out he used gay/bi dating apps even a year before we met, I couldn’t see beyond that time but a year before I even knew him he was using these apps, I only recently found this out by checking our smart tv we bought with wedding present vouchers we were given, which nearly gave me a heart attack! I’m so up and down in constant state of shock, heartbreak and anxiety since, but I have got a counsellor for me. He logged himself into the tv and must not of known what he was opening himself up for, or I wonder did he want to be caught deep down? But I wouldn’t have known still if he had not logged himself in. There it was actual proof of his activity - him on Grindr before he even proposed, during the wedding planning, 2 days before the wedding and a few days after we got home from our honeymoon. And right up to my confrontation. I tortured myself looking at these but had to as know he knows exactly how to manipulate my love for him. He could still be doing it on one of his multiple emails I found and the 2nd phone that I seen registered to his App Store. All this he denied and said it’s an old phone he never got rid of for back up! Back up!!! Eventually he acknowledged some but after telling me he would contact google as “my phone must have been hacked” seriously! And basically i seen Grindr was there before we met and right up to when I confronted him, all those years to when I caught him and that’s just what I could prove!. He’s deleted all activity and changed ALL passwords so I’ve no way of knowing if he is still doing it, he well could! I incovered some disturbing details of times events. He’d text and see when I’d be home then boom I’d see the Grindr activity matching all these times, other times many time I was home and sitting across the room from him which actually hurts the most. My family loved him from day one as did I. I thought he was mine but now I’ve found out after I confronted him (first he denied & lied and he’s still lying about some things now) he told his family I was “depressed” which wasn’t true I was and am heartbroken and under severe stress due to my husband living a double life. I moved out but it’s so strained. He told me now just very recently he was abused as a child and he said me and his therapist are the only ones who know - long story but I asked him this early on as it was relevant to the situation and asked about his first time etc which he told me all manner of stories all harmless and I told him mine etc but never a word about any childhood sexual abuse. I know people do bury those unresolved traumas too, but 6 years and proposing to a woman who doesn’t know this happened to you - I think that’s very odd. I’m not unapproachable by any means when it comes to talking about ANYTHING! It’s actually part of my day job & he knew all this though! Although once I did speak to him again he acknowledged some lies, he swears he only used Grindr and other hookup apps to send photos of himself for confidence/ validation but I know he used this app in other countries when he was away from me. I can see and have proof of times where he’d stop texting me and sure he’s on Grindr and so sneaky and clever to download & delete each time! I don’t know him at all, abuse is f**ked up but why propose and lie to me all these years? And hide his sexual abuse that happened 21 years before we met, and he said the memories came back to him a year before we met. He plays games and is not a silly man, extremely intelligent and can turn around conversations and only yesterday said “why did you invade my privacy?”, not why did he think it was ok to drag a young oblivious woman into his life and put pressure on me for children straight after the wedding all while unknown to me he was on Grindr behind my back. His mother contributed to making comments about my lack of trying hard enough for babies which were very hurtful & so inappropriate! We both come from very fertile families with no known issues but after coming off the pill and still no baby after I spent hundreds going to a private fertility clinic to be checked out - only to be told there’s no issues that should be stopping me and that it’s most likely work stress and the pill needs to leave my body over time naturally. 2 years after this I’m still off the pill and not pregnant. We’re sleeping in separate rooms now I had to move back as there’s a few decades on the mortgage left and haven’t found anywhere in budget to rent temporarily as of yet. He could be very cold at times and seeing the dates / times of his app use it breaks my heart, it was consistent wether we were happy/ not so much/ on our 2nd anniversary weekend away he used Grindr and ignored me and was horrible to me but lovely to all hotel staff which killed me. He also lied about a stripper on his stag - told me there was none then I find out a year after my wedding there was a stripper in his hotel room (where prostitution is fully legal)! This came from him when he was drunk after a great night out on holidays just us two, in 2019. He knew I was having a great time and I actually said “I can’t remember when I was so happy” and boom he said “I told you I had a stripper didn’t I?” I lost it - he knew full well he not only didn’t tell me, he told me I was possessive and crazy for even thinking that! It was a female stripper by the way, more confusion! And then I find out all his family knew but hid it from me, lots of men get strippers I don’t think it’s classy or nice on the person stripping for money but it’s a service and so many available, and you can’t control a best man so I don’t understand why he wasn’t just honest instead of lying for over a year! He also used to look at his ex’s fb’s early on in our relationship which freaked me out and I told him that’s messed up I basically broke up with him and he begged and begged for days for me to talk to him so he could explain why! he’d always have an excuse for how they hurt him and have caused him issues but I’m the only one he loves etc... so confused! “We talked about this already” & “you always bring up the past” are some of his favourite shut downs for me! The next step before all this was to start a family and he’s all for that still and moving forward he wishes it would be just swept under the carpet! as I’ve told him I’m not getting over this and struggling and need couples counselling as well as our own personal. I could not bring a child into this mess! I now worry about everything and is he gay but in the closet because of his religious family? Am I his beard? Is he bi and in denial? Either way he shouldn’t have proposed, and make it clear he felt he didn’t want a long engagement. So we got l married a year later, the venue I loved had availability and he was happy it was so close. Now I wonder why, he’s less than a decade older than me and said he didn’t want to be so old getting married, all seemed genuine! Do any gay men have an opinion on this behaviour please? He told me he would chat to men and get validation about his body then block them but as he deleted all the apps he can’t prove anything! My gut tells me it was a lot more but with no proof of messages only app details I can’t prove he did! Is he just bull shitting me totally? Should I go ahead and just leave ? Continuing to pay half a mortgage and rent which will leave me not with much but I could work it eventually. Until things are finalised anyway about the house we own jointly. Will he ever stop this behaviour if he done it during our “honeymoon period” literally most days since we met/ before he proposed ! I read a lot recently about men looking at gay sites when their partners are pregnant and I’m terrified he just wants my womb and half the mortgage paid basically!!! Just to add - he swears it was all cyber that he never physically cheated on me with anyone (must add though he NEVER stayed out all night/ home too late/ rarely goes out / not a big drinker) but I struggle to believe anything since I’ve uncovered so many of his lies! Anyone any input?
2020.10.11 19:28 1star_of_the_sea3Was this an experience with a DA?
Hi All, I hope you're keeping well and safe. I've been keeping this all to myself for a while and just need an outlet and some insights to help me move on. Please bear in mind I only discovered attachment theory about a month ago. It's a bit of a long story. I met a guy via online dating last Sep 2019, at the time I had just broken up from my first long term relationship a few months prior, so I wasn't looking for anything too serious. Looking back this guy love bombed me at first, he really wanted to impress me - wined and dined me, was so intricate and creative with dates, always planning the dates and initiating contact. Showed lots of PDA and started talking about future, travel plans and family... I tried to pace him, but I did get sucked in - I had never experienced this type of attention before so I enjoyed it + there was SO much chemistry it was magnetic. We were so different yet so similar, taught each other so much and had some interesting conversations. I felt that he noticed really detailed quirks about me that he said he loved, which I found so flattering. After about 5 weeks the first incident of ghosting happened. We had a date, time and place confirmed for dinner and the morning of he acted as if he had forgotten and asked if I was free 'at some point this weekend'. He said he had to help a friend pack as he was moving countries, I told him not to worry and that I understood but I am a tiny bit disappointed that I wouldn't get to see him that weekend because I really wanted to and had plans for the rest. A couple of days passed, and I noticed he hadn't reached out since so I drop him a text asking how he was and received nothing back, 2 weeks went by until I got a really long message. He said it's not like him to ghost and he's very sorry for that, apparently I had triggered him when I said I was disappointed and he didn’t like himself for doing that but that's his life story so far. All his previous partners, friends and family say/ have said that to him because he's always busy and puts his career first. He was also overwhelmed because he couldn't get me out of his head and kind of broke off continuing getting to know me but wanted to check in and let me know that he hopes I don’t think this has anything to do with me. He said I was a truly unique person, not to change and that he enjoyed every moment we spent together and that it is his loss. He said that he wanted to change but he can't. I should have accepted that nice apology and left it like that but of course I didn't. I told him that I felt he overreacted and to me the incident wasn't a big deal, I really had been enjoying getting to know him and it was a shame it was cut short for something so minor. I asked if we could continue to be friends because he was such an interesting person. He agreed but doesn’t know if he can be just friends with me. He said he doesn't have the energy to plan dates anymore - I said that was fine and reminded him that it was him who put that pressure on himself in the first place as I told him from the start I didn't want to get too serious too soon. We continued to see each other every now and then, I still tried to date others here and there as we weren't exclusive and he always put his career first so would only see me on his terms every couple of weeks and cancelled on me a few times (usually putting his friends first). One morning he had cancelled on me and I saw that he had changed up his dating profile, I was SO upset but never told him, after all he didn’t owe me anything. I was accepting breadcrumbs because I wanted him in my life and to be honest, I was only dating others to get my mind off him. After all he told me who he was after the first ghosting incident but I liked him too much to let go. We definitely weren't just friends, at this point we had gotten intimate and had spent some weekends together - he still insisted on taking me on lovely dates but was always the first to say he had to leave. He also still initiated contact almost daily, constantly gave me compliments and told me that he didn't understand why I wasn't annoying like other girls. I think he found this frustrating and wanted reasons not to like me. The most intimate moments weren't even sexual we had this bond when it came to cuddling, we could do it for hours - he said my cuddles were like therapy to him and that he would only allow me to do that with him. After a beautiful weekend spent together in December he went away for Christmas/New Years. As soon as he landed back into the country he got off the plane after a 16 hour flight and travelled miles from the airport with a suitcase to have coffee with me. It was then when I told him that I really like him and I felt connected to him physically and mentally. He then proceeded to tell me that he has never loved any of his previous partners and has always just said he loves them back to keep them happy and that he doesn't want to hurt me. He then ghosted again for another 2 weeks. Side note: He had a very long term relationship with someone that he lived with for 8-10 years, how could he not have loved her?! After that between Jan - April 2020 it was the same old, continued to date him here and there - he would cancel sometimes. Sometime in between I asked him why he was trying so hard not to let nature take it's course - he acted head over heels into me when we were together but when we weren't I felt like there was this invisible wall between us. He said he knows, and I am right but his priority is his career and personal projects. Opened up to me about some childhood issues, said that he is like this because he felt that his mother never liked him and his dad was away at work a lot. His parents never told him they loved him. He wants to feel emotions and intimacy with me but he can't - it's crazy because I feel like there was so much of it when we were together! When the pandemic hit he started messaging less, he told me he was feeling overwhelmed by the constant messages he was receiving from friends and family so wouldn't be on social media or messaging apps much but told me that if I want to talk to him I should call him. Then in mid-April he ghosted me for the 3rd time and for good until this day. It's been 6 months, the last conversation we had was about a book so it happened out of the blue and just a couple weeks prior we had spent a beautiful day together full of laughter, chemistry and fun. I've reached out a few times but no response, he hasn't posted anything on social media since that time which is unlike him because he used to before. He’s watched all my social media activity for the past 6 months and goes through phases where he is the first to watch seconds after posting. It really hurts that he couldn't tell me that he couldn't continue to speak to me anymore, I have worked on my self esteem over the years and I'm glad I met him after I had healed from all my past traumas and I'm trying not to take this personally but I do feel disregarded like a piece of trash :( I think about it over and over again, creating scenarios about what could have happened. Did he get back with that long term ex? Had he met someone else? I told him something personal about my childhood a few days prior to the ghosting – did this trigger his intimacy fears?
2020.10.04 12:24 IwasThrownAwayAgainMy (27F) ex(23M) wanted to catch up and acted like we were getting back together, instead he doesn't want to see me again.
Throwaway because I'm feeling vulnerable. Reddit I really need your help on making sense of this, because I'm honestly heart broken all over again. Sorry in advance for how long this is... I came out of a 4 year relationship in July 2019 with someone as I just fell out of love with him and realised we weren't compatible. In September 2019 I went to a festival and met 'James' in the crowd, he asked for my socials and he would chat me asking to catch up for a drink, and we would talk pretty regularly but I told him he was too young for me - however he was very persistent and in November I finally agreed for us to catch up. He had explained that he himself had only just gotten out of a relationship in August, and wasn't looking for anything serious as his last 2 ex's told a lot of lies and cheated on him. Given his age and how recently single I was too, I was more than happy for a casual fling. He's not my usual type so I thought I'd be safe in not getting emotionally attached, however as it turns out he possessed a lot of qualities that I love in a partner - he would make my bed every morning, cook me dinner every time he came over, he loved to read and he was really motivated at work and going to gym. James was adamant on us not 'dating' because he wanted to stay single and 'work on himself', so whilst we were seeing each other we never went out in public. He didn't want to meet each others family (we both lived at home) so worked it around when they were out. We spoke every single day, all day across texting, instagram and snapchat simultaneously. The first week that James and I caught up, I had slept with someone else that same week. I never slept with the other guy again because I knew I was really into James after the first time I met him. At this time, James was referring to me as his 'fuck buddy' to his friends essentially, and as I said, he didn't want any commitment. However the first night we caught up he said in 4 years you'll be the girl I'll marry. As weeks progressed, I was seeing him 1-3 times a week. One night he came over to my place after I got home from a festival. That night the sex was like literal love-making, he said so himself, and I knew that's when I was starting to get feelings, but also remained completely in denial telling myself that we've only been seeing each other for 3 weeks... if it ended I'll be totally fine. As I could feel my feelings getting stronger, but knowing he didn't want anything further with me, I distracted myself by talking to other guys. I went on a date with a guy to dinner, I hated it and never spoken to him again after. For Christmas I booked us a night away at the beach so that we could have crazy sex and chill at the beach before we head home. Whilst at the resort, we actually went out to dinner which we've never done, and he actually enjoyed it. That night we had a few red wines and he actually started crying, opening up to me about a friend of his that was killed, and I could feel us getting closer. Whilst we were at the beach, we spoke about a small disagreement we had a week earlier where he told me that even though we would both be at the same festival over New Years, he wasn't going to see me or talk to me as he just wanted a 'boys' trip and not feel like he had a girlfriend. However he still wanted me to drive him and his mates home on New Years Day because it was a long drive and they would have been under influence. I was quite upset that he was basically going to ignore me for 3 days at the festival but then still wanted my help after, but at the beach I said fine, you can hook up with whoever you want, and I will too and we'll just do our seperate things. He just nodded his head and said okay. On Xmas Eve he said that he didn't want to hang out with his friends this year and would rather see me. So we spent the day together and he said he couldn't handle us getting with other people and if that's what I wanted to do, then we would need to end things. I said I was happy to be exclusive with him. He said he still didn't want a relationship and that we would probably need to end soon before things got too hard, and we left it at that. As I'm a very honest person, I told him that I had slept with that one other person, and went on that other date. He was visibly a bit upset and said that he hasn't even looked at another girl since he started seeing me, but that he was grateful I told him. On Christmas Day I met his family. At our NYE festival he stuck to his word... basically pretended I didn't exist for the entire 3 days. One time I ran into him in the crowd when I lost my friends and he was so awkward and ignored me, followed by him telling his friends about this girl he was hanging out with at the festival and how funny she was. I asked if he had hooked up with her because I was feeling insecure given this was supposedly his 'boys trip', he said no but was now concerned that I had hooked up (I hadn't). He told me he would see me for the countdown (never did), so I told him he could come into my tent whenever he was wrapping up the night to sleep with me. At 4:30am he rocks up completely out of his mind, and proceeds to tell me that he thinks his feelings are too strong to continue being FWB and has been thinking that it would be silly to throw away a potential great relationship with me because of his insecurities of girls betraying him. He cuddled me that night like he never had before, and I was literally over the moon. For the first week of January, he kept going back and forth between wanting to be with me or being 'unsure' if this is what he really wants, with his securities at an all time high thinking I was always off with some other bloke. He told me he was so upset I had slept with someone else early on, and he doesn't think that I feel as strongly about him as he did about me. I explained that I barely knew him when I slept with someone else, and to trust me that my feelings were genuine. That weekend he then met some of my friends after a night out. The second week of January I went to Adelaide for a few days, when I came back he came over and broke up with me. Saying he just couldn't do it and needed to be alone and work on himself. I pretended to be okay, but he couldn't bring himself to leave my house so he stayed the night as 'one last night', I cried throughout the night and he held me in his arms and played a meditation track to calm me down. The next day after both of us were crying and holding each other, he left. However he never stopped talking to me, saying he feels like he made a mistake. The third week of January I went to Sydney for a few days, and he was messaging cute things non-stop, and so I felt like we were back on. I saw him on the Friday night when I got back and was expecting him to say he made a mistake and wanted to try again, however he kept telling me he was unsure of what he wanted still. I ended up sleeping in another room because I was so upset, and on Saturday morning I received a text after he had left for work saying he couldn't do this anymore. However by that afternoon he rocked up to my house, and confessed he made a mistake and wanted to make this work. I was completely shocked, and after spending the day bawling my eyes out, I agreed to give it another chance. The fourth week of January was Australia Day weekend. He was hosting a party at his house, and I was waiting for the invite... that never came. We discussed it on the Friday night (party on the Saturday), and he told me it's too soon for me to meet his friends as they've already met his ex's before me and I would be 'another girl' for them to meet. Again, I was upset and his solution to me being upset was suggesting we take a break... for my own benefit. I could barely sleep I was so angry and proceeded to basically ignore him the entire weekend. He called and texted asking what was wrong and I said we could talk after the weekend. He was pretty distressed and on the morning of the party had ended up asking me to come, by which time I had already made plans with other friends and said no, it's too late. He came over on the Monday pretty stressed, I said this is bullshit and he needs to do better or we're over. He declared he wanted to make it work and would make more effort. The fifth week of January, things seemed okay until the weekend. We went on a walk in the mountains and he started complaining about how I had so many guy friends (some of which I had hooked up with previously) and he was so uncomfortable given his ex's cheated on him. I tried to explain I would never do that to him, but eventually conceded that he was right and I shouldn't have so many close male friends. He was steering the conversation in a direction of we have different values and therefore we probably wouldn't work out. However he didn't end up breaking up with me. First week of February things are okay, but I notice his behaviour changing to be very hot and cold. We go on our first actual date and go to the beach. I'm a very affectionate person and he's always told me that he hates PDA and isn't affectionate at all, so trying to get a hug or a kiss from him was just almost unbearable for him. That weekend I could feel he was off so I asked him what's wrong, he tells me he's still so unsure because he feels like he needs to be single. We slept on it, and by this point I was absolutely riddled with anxiety and so sad all the time from being broken up with every weekend, that I sent him a text on the Sunday night and ended it despite that I knew that I loved him, telling him I needed someone who could love me back. He messaged back saying it was for the best and he hopes I find someone who makes me happy and that he's going to get therapy for his insecurities. My birthday was 4 days later, I didn't hear thing. At the end of February we caught up to give some things back to each other. We had closure sex and he then told me he felt relieved that we weren't seeing each other anymore and a weight has been lifted, and then I pretty much never heard from him again. This brings me to last week. Up until this point, I still thought about him every single day and my feelings had not diminished at all. I can honestly say I'm so much happier not being anxious all the time, but I really missed him. I spent all of this year trying to work on myself, to love myself, and I can honestly say I've come so far as I never want to end up in that situation again where I was treated less than I deserve. Last Saturday I was swiping away on Tinder, and James's face pops up on my screen, however it's not his profile... it's a friend of his that had James in his main photo. I never met this friend, and curiosity got the better of me wondering if he knew who I was so I swiped right and we matched. I wake up on Sunday morning to a message from his friend saying 'James misses you and wants to catch up'. My heart was throbbing, however another message came through saying 'nah just joking, but I want to catch up with you'. I ended up messaging this conversation to James saying that I didn't want him getting some twisted version of events thinking I was trying to get with his friend, and he replied to that message adding in that he does want to catch up with me. He tells me he quit his job and started a successful business, and has moved out of home right at the end of my street! James has always made it very clear that he does not stay friends with his ex's, so the fact that he wanted to see me after 7 months of no contact made me think that maybe he's had his time alone and wants to be with me properly. We caught up last night, and everything was incredible. He was so affectionate with me - kissing me while we sat at the park, holding my hand, couldn't sit near me without touching me. He told me how beautiful I looked, and made comments that back when we were seeing each other that he was clearly a man who was unsure of what he wanted, implying that now he did know what he wanted, and he was asking about every aspect of my life taking an interest. We went home and cuddled watching a movie on the couch. Things started to get a bit steamy however I stopped and said I wasn't ready to take this to the next level again yet. He said no worries, and we continued to make out and ended up doing oral. It was after that he says 'I just wanted to address the elephant in the room and be honest and let you know, I can't promise that I'll ever see or speak to you again, this is a once off thing'. He then said it was just nice to see another person after being in isolation for so long. My heart literally broke. He then continued to tell me that my feelings were obviously always stronger than his. He laughed as he reminisced on ignoring me at the new years festival, and giggled at how badly he treated me by not making effort when we were trying to make it work, followed with 'I don't know what you saw in me'. But as he left my house he's telling me he was really glad that I seemed so happy in myself now. I could barely sleep last night and again I'm so hurt. I ended up messaging him today asking him why he would be so kind and affectionate to me and doing all the things I always wanted, fully knowing that he wouldn't see me again? I also said his comments that I clearly liked him more and his laughing to his hurtful actions to me was really upsetting. He's completely ignored me and not replied. I honestly thought he had felt the same about me and now he was ready to be with me, and now that he's gone again I feel completely heartbroken just like I did the first time. I know a lot of you are wondering why I kept giving him second chances. He just seemed so genuine in how he felt about me, and he was always unsure due to thinking he had to be single and his insecurities of women hurting him. So I tried so hard to show him that not every girl will betray him and wanted to support him as he was struggling. My question is to the men of Reddit... what is his thinking behind all this? He never wanted other girls and wanted to be alone and work on himself. Then why did he keep telling me he wanted to make it work? To the ladies of Reddit, why on earth am I so hung up on this guy who clearly doesn't treat me well and does not feel the same about me? TL;DR: I fell for someone who I thought felt the same for me, however he continually broke up with me and then wanted me back. He asked to catch up and again and was acting like things were better than before, only to tell me he never wants to see me again.
2020.10.01 01:58 NextOnesNetworkEric Demers Gordon College 2019 - 2020 Highlight Montage NCAA Scoring Champ!! (All Levels)
https://nextones.com/video/_zjjiObUnBw For the 2019-20 season, Eric Demers played his senior year with the Gordon College Fighting Scots. The Acushnet, Massachusetts native averaged 32.4 points, good for the highest average on all levels, on 44.8% shooting from the field,40.7% from three, and 88.5% from the charity strike. He also averaged 5.6 rebounds, 1.8 assists, and 1.8 steals per game. The 6’2” guard’s legendary season was capped off with the Commonwealth Coast Conference POY award and receiving a first-team all-conference mention. One of his best games of the season came in a win against Nichols. Eric dropped 49 points on 52% shooting from three,58% shooting from the field overall,10 rebounds, and a block. Follow the link below for another one of Eric’s highlights! Eric's 42 pts vs Hartford Hawks - https://nextones.com/video/GScPdaNOMe4 Next Ones is a player discovery network built by players for players and their fans. Discover players across all leagues on all levels from around the world.
2020.09.24 04:31 AutoidSeuicLogistics for E-commerce Industry by Handheld Computer
As a practicer of smart logistics, Seuic is committed to push the intelligence of logistics enterprises with efficient data collection. Seuic started from infield scenario with worst application environment and the most frequent usage through mobile computer, successfully solved the issues of improving manual working efficiency, optimizing actual operations, reducing enterprise operating cost, etc. Seuic wins customers' recognition and high RFID reader market share while improving the intelligence of logistics enterprises! Typical Cases SF Express Seuic have customized three generations of handheld terminal for SF, the fifth generation is PDA+POS integrated equipment; the sixth generation combines the courier mobile and PDA into one and adopted PDA+MPOS solution. The seventh generation mobile computer is compatible with the internal and external fields. It is lighter and slimmer with more powerful scanning capability. We won the Technology Leadership Award from SF in 2016. Mr D Food Mr D Food is SA's #1 food delivery service, favored by over 1 million South Africans. It is a tech centered, people focused food delivery company, Mr D Food started life as Mr Delivery, the pioneers in South African food delivery, delivering meals from restaurants to customers around South Africa. (New)AUTOID9 android handheld terminal is applied for picking and delivery links with its precise and quick recognition. Also can be used as handheld computer to the order picking, receiving and delivery of retail logistics, the goods are intelligently sorted, checked, and received. JD Logistics JD Logistics is the only company in the world with six logistics networks of small and medium pieces, heavy cargo, cold chain, B2B, cross-border and crowd sourcing. With CRUISE™1-(P) handheld rfid reader volume measurement module, JD service site can measure the volume in a easier and more precise way instead of calculating manually. Deppon The largest LTL logistics, Deppon, is a customer of Seuic for many years. AUTOID Q7-(S) handheld computer is applied in the busiest part of Deppon express—Transit Center. In this field, customers consider more about the grip, WIFI & scanning performance, human-computer interaction and battery life. Seuic provides efficient & reliable mobile computer for real-time data capture & uploading. In 2019, we won Deppon's Excellent Supplier Award.
2020.09.22 05:56 morshedulpythonWatch NFR Live Stream 2020 Texas Rodeo Onlin
Watch NFR Live Stream 2020 Texas Rodeo Online
https://preview.redd.it/2rj1w5a2hmo51.jpg?width=640&format=pjpg&auto=webp&s=54c4898d92e256fd00af0a9b6036c4325887a50c When talking about 2020 Rodeo is basically it basically refers to an annual [National Finals Rodeo](https://nfrliverodeo.com/) event that is meant to happen on Thursday, December 3rd to the Saturday 12th at the Globe Life Field which is located in Arlington, Texas, United States. Additionally, the scheduled event is supposed to cover about Bareback Riding, Barrel Racing, Bull Riding, Saddle Bronc Riding, Steer Wrestling, Team Roping and Time-down Roping. Importantly, NFR live stream 2020. The NFR is shaping up to be one of the most competitive and entertaining rodeos that the world has ever seen. The top cowboys in the world will be putting their boots on and taking each other on to try and claim a world championship in their respective events. Mark your calendars and make sure you do not miss out on a single second of action this December. Long before the Dallas Cowboys were winning Super Bowls in American football, real-life cowboys were competing in the “Super Bowl of Rodeo” in Dallas, Texas as early as 1959. The seven-competition tradition began there, but also saw stops in Los Angeles, California from 1962 to 1964, Oklahoma City, Oklahoma from 1965 to 1984, and Las Vegas host since 1985 but in 2020 The National Finals Rodeo will move from its usual home in Las Vegas to Globe Life Field in Arlington in what would be the park’s first major non-baseball event since its opening this past spring. Rodeo fans are eagerly waiting to see theNFR live stream. The National Finals Rodeo is not the only showcase of the best cowboys but also showcase of patience, bravery and spurs. https://preview.redd.it/0iu4d9h3hmo51.jpg?width=1200&format=pjpg&auto=webp&s=3973adb40d31c07bd721194cd1115ac28f45ea98 Venue Globe Life Field, Arlington, Texas, United States Start Date Thursday, 3rd December 2020 End Date Saturday, 12th December 2020 Broadcast The Cowboy Channel Live Stream Watch Here So, don’t miss a single moment of the WNFR live action. Don’t worry, If you can’t attend in Texas NFR, we’ll discuss here how to watch National Finals Rodeo online real-time TV coverage. Contents [hide]
1 When is the National Finals Rodeo?
2 Where will the NFR Texas 2020 be held?
3 What TV Channel will the NFR be on?
4 How to watch NFR Live Stream 2020 Online
4.1 The Cowboys Channel
4.2 PRCA on The Cowboy Channel+ App
4.3 RFD-TV Now
4.3.1 Supported platforms
4.4 Sling TV
4.4.1 Supported platforms
4.5 2020 NFR Live Stream Using a VPN
5 Can I listen to NFR 2020 live stream on radio?
6 NFR Live Online on Social Media
7 How much are tickets to the NFR?
8 Everything You Need to Know About NFR
9 Main Performance
9.1 Bareback Riding
9.2 Steer Wrestling
9.3 Team Roping
9.4 Saddle Bron Riding
9.5 Tie-Down Roping
9.6 Barrel Racing
9.7 Bull Riding
9.8 All-Around Champion
11 Super Bowl of Rodeo
12 Miss Rodeo America
13 Wrangler NFR Preshow
14 Cowboy Christmas
16 NFR Prize Money
17 Wrangler NFR World Champions
18 Final Words
When is the National Finals Rodeo?
For individuals who plan on attending the NFR festivities in Texas, there are a variety of sponsored activities to get involved with during the 10-day period between 9:00AM to 5:00PM (PT). Each night’s NFR performances will officially take place between 6:45PM to 9:00PM (PT). See complete NFR schedule page.
Where will the NFR Texas 2020 be held?
All of the NFR’s main performances will take place at the Globe Life Field in Arlington, Texas. Normally home of the home of the Texas Rangers baseball team, this venue can seat up to 40,300 people and tickets will go on sale to the public on Sept. 25, 2020.
What TV Channel will the NFR be on?
The Cowboy Channel is the official media partner for the PRCA and Wrangler NFR 2020. Because this is an exclusive deal between the network and the PRCA, the NFR will not be shown on any other TV network during the 10-day period.
How to watch NFR Live Stream 2020 Online
The Wrangler NFR is a 10-day event that includes the fan-favorite Cowboy Christmas as well as the PRCA National Convention. The schedule also includes nightly Buckle Presentations, Benny Binion’s World Famous Wrangler NFR Bucking Horse Sale, the PRCA Awards Banquet and Gala also the Pro Rodeo League of Women Style Show and Luncheon. All performances will be covered by The Cowboy Channel live and simulcast on RFD-TV. Wrangler National Finals Rodeo (NFR) move to The Cowboy Channel (TCC) and RFD-TV beginning in 2020. The performances will also be streamed on the PRCA on Cowboy Channel Plus app. The PRCA on Cowboy Channel Plus app users will be able to stream events both live and recorded.
The Cowboys Channel
The ultimate annual rodeo event will now be seen by millions of people live simultaneously on two national TV networks. Also included in the deal is a wide variety of other PRCA programming, including expanded live coverage of the PRORODEO TOUR and the PRCA’s Xtreme Bulls Tour events which will result in a huge increase in the amount, availability and quality of PRCA PRORODEO coverage on The Cowboy Channel here. The Cowboy Channel now available on Dish Network-232, Direct TV-603, Cox-260 anytime, and anywhere. You can enjoy Rural Media on these platforms:
AT&T (Channel 568 & 1568)
DIRECTV (Channel 345)
DISH (Channel 231)
Sling TV’s Heartland Package
To find out if RFD-TV and The Cowboy Channel are available in your area, please click here and enter your zip code also choose your Pay TV provider.
PRCA on The Cowboy Channel+ App
The PRCA on The Cowboy Channel+ App will keep fans up-to-date with their favorite PRCA rodeos and athletes, as well as provide behind-the-scenes access to livestreamed and on demand PRCA rodeo events from around the country. The content can be accessed via the mobile app (available on Android and iOS), as well as any browser, smart TV or device. Viewers will be able to enjoy free access to up-to-the-minute news, bios, rodeos and highlights. Those with a subscription will unlock premium content such as up to six simultaneous live rodeo feeds, classic PRCA archived rodeos, The Cowboy Channel video-on-demand programming, and the only place viewers can stream the National Finals Rodeo (NFR). The Cowboy Channel+ is available for only $9.99 a month or save up to 25% and purchase the whole year for $89.99. To sign up for the PRCA on The Cowboy Channel+ App, visit www.cowboychannelplus.com.
RFD-TV Now delivers both real-time NFR 2020 LIVE programming as well as an expansive on-demand library with access to more than 90 shows such as Hee Haw, Opry Encore, The Best of the Marty Stuart Show, Ag PHD, and FarmHer, as well as daily broadcasts of Market Day Report and Rural Evening News. RFD-TV Now is available on a huge lineup of streaming players and devices including Roku players, Roku TVs, and Amazon’s Fire TV. RFD-TV Now costs $9.99 a month or $89.99 a year. Supported platforms Can I watch RFD-TV on Roku, Fire TV, Apple TV, or Chromecast? Yes! you can here is the complete list:
Android TV 5.0+
Apple TV 9.0+
Amazon Fire TV
Web: Chrome, Firefox, IE11, Edge
Sling TV includes RFD TV as part of their Sling Blue Heartland Extra package for $35 a month. Sling TV has 30 channels as part of their plan, including A&E, AMC, BET, Bravo, Cartoon Network, CNN, Comedy Central, Discovery, Disney Channel, E!, ESPN, Food Network, Fox News, Freeform, FX, HGTV, History, Investigation Discovery, Lifetime, MSNBC, Paramount Network, Syfy, TBS, TLC, TNT, Travel Channel, truTV, and USA Network. This is the full Sling TV Channel List. Every Sling TV subscriber can record to their 10 hours Cloud DVR, while 3 users can stream at the same time. Supported platforms Sling TV supports a wide-range of devices to stream including Amazon Fire TV, Apple TV, Google Chromecast, Roku, iPhone/iPad, Web Browsers, Android Phone/Tablet, Android TV, Xbox, Samsung Smart TV, LG Smart TV, and VIZIO Smart TV. Sling TV is not available to stream on PlayStation and Nintendo.
2020 NFR Live Stream Using a VPN
Sling TV is only available to residents of the United States. Even viewers located in our neighbor to the north, Canada, cannot access the Sling TV service. In these situations, a reliable and encrypted VPN (Virtual Private Network) can prove to be helpful. A VPN will allow an individual to remotely connect to a server located in a different country that allows the desired website viewing to take place. The following VPNs can prove to be very useful:
This source offers a selection of servers that spans over 90 countries. Currently, they offer monthly ($12.95/month), semi-annual ($59.95/6-months), and annual ($99.95) plans. Included with each plan is the offer of a 30-day money back guarantee in the event that a user is dissatisfied.
The offering from this source includes servers that span over 60 countries. The current subscription plans consist of monthly ($10/month), quarterly ($26.99/3-months), and annual ($77.99/year) options. Included with each plan is the offer of a 7-day money back guarantee in the event that a user is dissatisfied.
While maintaining a selection of servers that spans over 60 countries, this VPN source currently has subscription plans that consist of monthly ($11.95/month), semi-annual ($54/6-months), annual ($83.88/year), and bi-annual ($95.75/2-years) options.
Once you have connected to US’ Fastest server, the Sling website will instantly be accessible to you. Simply subscribe to Sling Live TV service and enjoy live streaming of all your favorite TV channels right at home!
Can I listen to NFR 2020 live stream on radio?
This season, you can hear daily from the ten days of the Wrangler NFR, scheduled for Dec. 3-12 (find an affiliate near you), as well as on SiriusXM serving rural America and Canada and is available to more than 34 million vehicles and homes. RURAL RADIO also offers a broad slate of Western sports programming year-round featuring Western Sports Roundup and coverage of WPCA and PRCA events. Launched in March 2019 under the theme of “All Dirt, All Rodeo, All Year,” NFR Extra follows current and former rodeo contestants, country music performers, stock contractors, rodeo industry insiders and more. New episodes are released weekly with the plan to broadcast daily from the ten days of the Wrangler NFR, scheduled for Dec. 3-12. If not listening on RURAL RADIO Channel 147 on SiriusXM, NFR Extra can be accessed at NFRexperience.com or on Spotify, Apple Podcast, iHeart or anywhere fans like to listen.
NFR Live Online on Social Media
One increasingly popular method of viewing NFR live stream comes in the form of social media viewing. The way this typically works is through an individual using their mobile device to live stream the event to a social media platform of their choosing. The most popular platforms for this method are as follows:
The most popular video-sharing site on the planet has historically built its name upon uploaded videos. However, the site now allows live-streaming capabilities, making it perfect for free viewing of live events such as NFR, as long as a streaming user can be found.
Various individual accounts or pages are bound to be streaming the National Finals Rodeo events. Interested individuals will have to search for these opportunities throughout the platform as it gets closer to the festivities.
This platform has increasingly become the go-to place for action as it happens in real-time. That makes it a prime destination when searching for all things related to NFR. A quick search bar or hashtag follow will almost assuredly lead to the discovery someone streaming the NFR.
Mainly known as a news aggregation site, this platform has increasingly become a well-known discussion forum hub. Within those forums, there is undoubtedly discussion concerning how to watch the NFR live stream on Reddit.
How much are tickets to the NFR?
National Finals Rodeo Tickets have been placed on this website by our trusted brokers, who offer those tickets in a range of values. Have a look at all the ticket prices and select the tickets which best suit your budget. 2020 Wrangler NFR new ticket prices are as follow:
Beyond the payouts for the Cowboys, the PRCA estimates that the event brings in about $90 million annually to the Las Vegas economy. Furthermore, recent attendance stats have shown that 177,565 rodeo enthusiasts decked out in Wrangler jeans, Justin boots and cowboy hats attended events at the Thomas & Mack with an additional 40,000 fans who watched at the 40 hotels who hosted watch parties. It is during this rare time of the year that many marquees on the Strip have the face of bull riders replace DJs’ faces.
Seven main events have historically taken place at the NFR. Each event has its own monetary prizes that are paid out, and those payouts are determined by each top-placing competitor’s rank in relation to the event’s overall prize pool. Individuals placed in the top-six of a particular event are paid out accordingly, while individuals placed in the top-eight of the overall NFR are also paid out. The NFR’s main events are as follows:
This consists of a horseback cowboy using a bareback rigging as the primary means of staying on top of the horse. This grip has often been compared to the equivalent of hanging on to a suitcase handle and makes for the only support that a cowboy has on top of the wildly bucking horse. An 8-second ride constitutes a qualified ride and the cowboys is judged on riding technique.
This act involves a horseback steer wrestler, alternatively known as a “bulldogger”, bringing a fast-moving steer to a halt on its back as fast as possible. The bulldogger utilizes a combination of strength, technique, speed, and precision to jump off of their horse from a designated starting point and onto a steer sprinting off from the same starting point.
One of two horseback team members whose job is to successfully rope the head of the steer in one of three tries as fast as possible; around both horns, around one horn and the head, or around the neck.
One of two horseback team members whose job is to successfully rope the hind legs of the steer as soon as the header has successfully done their part. To avoid a 5-second penalty for roping only one hind leg, the heeler must rope both hind legs.
Saddle Bron Riding
Similar to Bareback Riding, the goal of the horseback cowboy is to maintain their balance as much as possible for 8 seconds while the horse is bucking. In this event, however, the cowboy sits on a saddle while using one hand to hold on to a thick rein that’s attached to the horse’s halter.
This event centers around a cowboy on horseback attempting to restrain a calf by throwing a well-timed rope loop that’s attached to the cowboy’s horse. The cowboy and the calf both leave from a designated starting point, with the calf getting a slight head-start. The cowboy depends on the horse to mitigate any slack in the rope after dismounting, then proceeds to tie-up the calf as fast as possible.
This is a women’s event where horseback cowgirls race against the clock to complete a strategically set course where barrels are set up as landmarks. The intent is for the cowgirls to complete a cloverleaf-shaped run around 3 barrels placed in a triangular formation as fast as possible. Barrels that are accidentally knocked over result in 5-second penalties.
The cowboy on top of the bull has the main objective of staying on top and maintaining their balance for 8 seconds. They are judged based on technique and can earn extra points by spurring while the bull is bucking. The cowboy stays on top of the bull by grasping a flat braided rope, which also wraps around the bull’s chest.
Being crowned the All-Around Champion speaks volumes about the versatility and high level of talent exhibited by the winning cowboy. In order to receive this honor, the cowboy must have won the most prize money in a given year and competed in at least 2 NFR events while earning at least $3,000 in each of those events. This is widely known as the highest honor bestowed by the PRCA.
There are 120 cowboys from all over the United States that will step foot as competitors within the NFR. A full list of the contestants can be found on the event’s Contestant Roster page. The top 10 ranked competitors are as follows:
Tuf Cooper – Tie-Down Roping
Trevor Brazile – Tie-Down Roping
Sage Kimzey – Bull Riding
Tim O’Connell – Bareback Riding
Jacobs Crawley – Saddle Bronc Riding
Caleb Bennett – Bareback Riding
Ryder Wright – Saddle Bronc Riding
Rhen Richard – Team Roping (Header)
Shane Hanchey – Tie-Down Roping
Brittany Pozzi Tonozzi – Barrel Racing
Super Bowl of Rodeo
The NFR has consistently been referred to with this phrase because of the sheer massiveness of its popularity and money-generating power within the context of rodeo. The event is considered to be so big and consistently sold-out that the UNLV basketball team that normally uses the NFR’s venue during the season has to annually build its schedule in a way that keeps the team on the road for the duration of the NFR festivities.
Miss Rodeo America
This event is a pageant that takes place in conjunction with the NFR as part of the NFR’s overall festivities. State rodeo queen winners from across the United States compete for the Miss Rodeo America crown and put themselves in line to potentially win $20,000, among other smaller prizes. In addition to the prizes, the winner is expected to travel to various rodeos throughout the United States and to promote the rodeo during the subsequent year.
Wrangler NFR Preshow
The former Miss Rodeo America titleholder is no stranger to the excitement of the “Super Bowl” of Western competition, with six years of WNFR reporting under her belt. She is most excited about bringing the pre-show to the fans. Be prepared for this Wrangler NFR Preshow, don’t miss a single moment of the Pro Rodeo live action.
For those that need a break from the constant adrenaline that comes with the NFR’s main events, the Cowboy Christmas experience allows for a welcomed change of pace. This portion of NFR centers around cowboy shopping and serves as a marketplace for hundreds of exhibitors from the United States and Canada to sell to thousands of eager buyers. Typically taking place at the Las Vegas Convention Center, Cowboy Christmas will also move to Arlington, TX in 2020. All exhibitors will have the opportunity to Opt-In/Opt-Out for 2020.
The 2019 PRCA season has been extremely competitive as a lot of the top cowboys are gunning for glory. Tuf Cooper sits atop of the all-around standings and many experts believe that he is going to win his second all-around title in a row. There will be a lot of close competitions and many of the world championships could come down to the last day. You can check the current standings here.
NFR Prize Money
The total payout for the entire event is $10 million and will remain at that amount until 2020. After that, the amount will be adjusted and remain in place for the subsequent five years. All 120 qualifying contestants receive $10,000 as part of participating. This year’s detailed payout structure can be found on the PRCA’s 2019 Wrangler NFR Payoff page.
Wrangler NFR World Champions
2019 All Around World Champion Stetson Wright The 2019 NFR World Champions Bareback Riding Clayton Biglow Steer Wrestling Ty Erickson Team Roping (Header) Clay Smith Team Roping (Heeler) Wesley Thorp Saddle Bronc Riding Zeke Thurston Tie-Down Roping Haven Meged Barrel Racing Hailey Kinsel Bull Riding Sage Kimzey For a full recap, please click here.
All in all, the National Finals Rodeo is a landmark event and a de facto defining period of time within any given rodeo year. For anyone who is a fan of rodeo, the main events and the surrounding festivities are must-see events and must-participate experiences if the financial means allow for it. Don’t miss a minute of the exhilarating NFR live stream action this year from December 3rd until December 12th.
2020.09.16 04:27 chulzleMY NIPT RESULTS SHOW THIS ABNORMALITY, WHAT DOES THIS MEAN? WHAT ARE MY CHANCES OF IT BEING A TRUE POSITIVE? WHAT SONO FINDINGS AND OTHER INFO TO LOOK FOR? SHOULD I GET CVS OR AMNIO? Individual chromosome results break down here. Results for Trisomy 21, 18, 13, X, no result, triploidy, XXX, XXY etc
** I wrote this up to anyone receiving their initial result, so they can refer to main post as well as this post for information** Main post here about NIPT and more info: https://www.reddit.com/NIPT/comments/ecjj5v/welcome_to_rnipt_the_sub_for_abnormal_nipt/ This post will contain chromosome specific issues for anyone first receiving the result. I will update more later when I have some more time, this took forever and I hope you all find it helpful!
MY RESULTS SHOW THIS, WHAT DOES THIS MEAN? WHAT ARE MY CHANCES OF IT BEING A TRUE POSITIVE? WHAT SONO FINDINGS AND OTHER INFO TO LOOK FOR? SHOULD I GET CVS OR AMNIO?
*** NOTE ON RESULTS FOR TRIPLE SCREEN LABS AKA NT SCAN, PAPPA, HCG IF DONE AT 11-13 weeks along with NIPT. NT AND TRIPLE SCREEN RESULTS TYPICAL RESULTS FOR TRISOMIES / MONOSOMY X and TRIPLOIDU https://www.researchgate.net/figure/Median-interquartile-range-maternal-age-crown-to-rump-length-NT-PAPP-A-MoM-free_tbl1_26833668 Above is a chart table of MOM is “normal” when that is 1 meaning 1 is an average along all normal pregnancies. This is called the triple screen and what is used to determine someone may be at risk for trisomy if a formula determines that all 3 tests are somewhat abnormal as well as your age. This is not the NIPT but the "usual" test done at 11-13 weeks. These are the values that may indicate risk. Median of mean is the middle / average. The above are averages away from this median of normal. Values are either decreased or increased but can also be normal.
Trisomy 21 NT high or normal, Pappa low or normal, HCG high or normal
Trisomy 18 NT high or normal, Pappa low or normal, HCG low or normal,
Trisomy 13 NT high or normal, papa low or normal, HCG low or normal
Turner’s X NT very high, Pappa Low or normal, HCG usually normal
Triploidy maternal: NT normal, low papa, low hcg
Triploidy paternal: NT normal, normal or low PAPPA, VERY HIGH HCG
Type 1 affects outer layer so "short term culture" of CVS. This is the most inaccurate result and should not be used to terminate a pregnancy if sonographic result is normal. Long term culture is more accurate, and is usually true in cases of trisomy 21 but may not be true in others making amnio a better choice. More on this below in each chromosome affected.
Type 2 makes NIPT normal, and really does not spark issues much since the outer layer is normal, and has a normal fetus.
Type 3 is WHERE THINGS BECOME PROBLEMATIC FOR CVS. Some chromosome CPM are prone to this - this is especially true for Trisomy 13 and 18. A normal fetus on sono with an abnormal CVS in long term culture should have amniocentesis to prevent wrongful termination. Both short and long term culture can be affected as trisomic and still have a normal fetus. More in each chromosome issues below and here is a quick summary.
Case 1 Both outer and inner placenta + for trisomy 18, amnio normal
Case 2 Outer layer monosomy x, inner layer mosaic for monosomy x, amnio normal
Case 3 Outer layer + 21 mosaic, inner layer normal, amnio normal = couple terminated despite genetic counseling telling them this is a healthy baby
Case 9 100% of inner and outer cells + trisomy 16 amnio normal
Case 10 100% inner and outer cells + trisomy 15 amnio normal
Case 12 100% inner and outer cells of cvs trisomy 16 amnio normal
Case 18 100% inner and outer cells of cvs trisomy 16
Case 21 / 22 100% inner and outer cells of cvs trisomy 16 and 13 but baby died in utero due to placental issues but had normal karyotype in fetus
Case 25 100% inner and outer cells of cvs trisomy 5, normal karyotype at birth
Case 26 100% 100% inner and outer cells of cvs trisomy 16 normal karyotype birth
Case 33 100% inner and outer cells of cvs trisomy 7, normal karyotype at birth precclampsia
NOW, for concerns regards screen positive results of NIPT for each chromosome of interest. YOUR RESULTS OF NIPT SHOW:
NO RESULTS, or LOW FETAL FRACTION RESULT from Natera/Panorama
TLTR: The most common NIPT concern,do not panic.Happens in 5% of Natera/Panorama and 1% of WGS (other system) NIPTs. The chances are 95% chance everything is fine. NT san and sono will very highly tell you that things are OK. It is reasoable to ask for redraw or amnio to ensure things are ok. If sonos are normal it is reasonable to not get amnio if you do not want any final confirmation. Natera/Panorama is a different type of a NIPT test (see main post). If fetal fractions are below 4% they give out this no results call. There are several reasons for this. Search this sub for "low fetal fraction" or "no result" and you will see all the examples come up. When this is reported, you are likely told you are at an increased risk for Trisomy 13, Trisomy 18 and Triploidy at 1/17 chances. Keep in mind that even those studies were done in high risk women so those odds are actually most likely much lower. This result is coming up in around 2-5% of all NIPT tests and you are not alone. Here is what Natera says: https://www.aruplab.com/files/resources/genetics/panorama/Patient%20Guide%20to%20Results.pdf For women where a result was not provided from an initial sample, whose risks were unchanged by the FFBR algorithm, and had an informative redraw, 2.1% had a high‐risk call from the second draw. This rate is similar to the rate (1.8%) previously reported for all women referred for NIPT (Dar et al. (2014)). This observation provides additional evidence that this group of women can be counseled that their uninformative result does not measurably alter their prior age‐related risk (McKanna et al., 2019). Since this is a "risk" for trisomy 13, 18 and triploidy - review the below about each of these which are very likely viewable on NT scan at 12 weeks. Trisomy 21 or monosomy x is NOT associated with no calls. So a normal sono at 12-14 weeks is also very much indicative that hopefully things are ok. Your risk with a normal sono at NT scan becomes extremely low since the 1/17 chance does not consider sonographic findings. It is likely that most if not all of those 1/17 would show sonographic findings as well as a no result/or low fetal fraction no result. Lastly, if you DID get a result and still have low fetal fraction with another company who does whole genome sequencing you are likely ok since Negative predictive value of NIPT is high and it basically did not see any abnormal cells in placental debris meaning you likely are not dealing with any placental trisomy or monosomy. NEXT STEP: REQUEST NT SCAN, REFERRAL TO MFM and GENETIC COUNSELOR IMMEDIATELY AND ALSO TRY TO REQUEST ANOTHER NIPT TESTING COMPANY THAT DOES WHOLE GENOME SEQUENCING INSTED OF SNP ALGORITHM. THIS IS ANYTHING LIKE MATERNIT21 PRENA ETC. BASICALLY ANYTHING BESIDES NATERA/PANORMA. If they are not able to use another company, try a re-draw if sonos are normal. At times with more passing time "fetoplacental" fraction can increase and you can get a result on re-draw. Some reasons for no results are
The reported failure rate with SNP-based NIPT was 6.4% in a series of 31 030 patients, and this was mostly due to low fetal fraction.9The failure or non-reportable rates of NIPT was quoted as 1.9% using massive parallel sequencing and 3% with chromosome-specific sequencing.1011It is estimated that 2% of pregnancies between 10 and 21 weeks will have a fetal fraction of less than the required 4%.5 More than 50% of women had a successful result on redraw after the first failed sample.6There was observed to be a mean 1% fetal cf-DNA gain in the second draw compared to the first draw, with an average interval of 3.6 weeks in between. At 11–13 weeks, the median fetal fraction in maternal plasma is 10%.5https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5174759/
Effect of maternal biology on the performance of NIPT
A small proportion of samples submitted for NIPT will not return an interpretable result. The most common reason for these ‘no call’ results is a relatively low amount of placental cfDNA in maternal blood, or low fetal fraction [fetal fraction = placental DNA/(placental DNA+ maternal DNA)]. Most NIPT assays require a minimum fetal fraction of 2%–4% for a reportable result. Any condition which increases maternal cell turnover without increasing placental cell turnover could theoretically reduce the fetal fraction and increase NIPT failure rates. While approximately half of women with a ‘no call’ result will obtain a successful NIPT result on redraw, those that do not obtain a result on repeat testing may lose the opportunity to access CFTS if their gestation has advanced past 13+6 weeks. This has important implications for pre-test counselling and choice of screening test for women at increased risk of failed NIPT.
+21 I have a Screen positive for Trisomy 21 NIPT “Down’s syndrome”
This is the most common positive result for NIPT as trisomy 21 is also the most common trisomy. \*WHAT IS THE RISK FOR A TRUE POSITIVE FOR A + SCREEN FROM NIPT FOR TRISOMY 21*\** TLTR: risk is based on age, PPV calculator below, if normal NT scan at 13 weeks, it could still be a true positive, if normal sono it is a bit more encouraging, can get CVS since not prone to confined placental mosaicism type3. Do not terminate after short term culture of CVS aka 1-3 day results since confined placental mosaicism type 1 aka short term culture is common. If you had a positive screen for NIPT for Trisomy 21 there is a positive predictive value calculator to estimate the risk for actual true positive vs a false positive that can be found here: https://www.perinatalquality.org/Vendors/NSGC/NIPT/ The risk of a true positive is directly related to female’s age during pregnancy.
NIPT + for 25 year old has a PPV of 50% (aka it’s a true positive only 50% of the time)
30 years old PPV 61% (false positive 39%)
35 years old PPV 80% (false positive 20%)
40 years old PPV 93% (false positive 7%)
NEXT STEP: REQUEST NT SCAN, REFERRAL TO MFM and GENETIC COUNSELOR IMMEDIATELY You should also have an NT scan which is a mini anatomy scan at 11-13 weeks. There are certain findings that make this result be a more likely true positive. TRIPLE SCREEN RESULTS ABOVE\) Here is information about pre-natal and post natal diagnosis of Trisomy 21. https://www.aafp.org/afp/2000/0815/p825.html Ultrasound markers commonly found in trisomy 21 (meaning none or any of these in combination or alone. A soft marker alone does not mean your baby has trisomy 21 or even several soft markers but can make it more likely to be true). Ultrasonographic Findings Associated with Fetal Down Syndrome
Intrauterine growth restriction
Mild cerebral ventriculomegaly
Choroid plexus cysts
Increased nuchal fold thickness
Echogenic intracardiac foci
Congenital heart defects
Increased intestinal echogenicity
Duodenal atresia (“double-bubble sign”)
Renal pelvis dilation
Shortened humerus and femur
Increased iliac wing angle
Incurving (clinodactyly) and hypoplasia of the fifth finger
Increased space between first and second toes
Two-vessel umbilical cord
INASIVE TESTING OF CHOICE OPTIONS: CVS or AMNIO CVS is most likely OK since the risk of confined placental mosaicism type 3 is extremely low in Trisomy 21 where both layers of placental would be affected but the fetus is not. Please check with your genetic counselors and MFM if they know of any of such cases. The caveat here is that Trisomy 21 can have a correction of something called trisomy rescue. This can result in 2 options leading to a normal 2 chromosomes 1 from dad one from mom or 2 chromosomes from one parent. This is called uniparental disomy. IT happens like so. Trisomy 21 is called a NON IMPRINTING GENE. Meaning most likely the baby ends up healthy (caveat is if the parent from which both of chromosomes come from is carrying some sort of a genetic disorder on chromosome 21 that would result in that recessive gene showing up with two copies presented and child could display that disease not at all related to trisomy 21). This is an example of something like this where NIPT was + for trisomy 21, UPD was found, patient counseled that this is likely OK but patient terminated the pregnancy anyway. ***In case of UPD 21, no abnormal phenotype has been reported so far” below:
This also brings up an example of how a CVS isn’t as accurate since some biopsies can be normal, or affected and NIPT therefore can be more sensitive to placental mosacism because it looks at placental cell debris. So all of those cells would be shed, normal and abnormal and NIPT will detect abnormal (but you can also have CVS biopsy showing a normal result and still have confined placental mosaicism). “Our case also demonstrated that NIPT, which studies DNA fragments coming from the whole placenta, is much more sensitive in detecting CPM then CVS, which only provide a limited sample. If the CPM were not known in the case, the NIPT result would have been considered to be a ‘false positive’ because the karyotyping of CVS was normal. Recently, Choi H, et al.6 also reported a ‘false positives’ case of NIPT for high risk of Down syndrome at first trimester due to CPM. Because CPM is probably much commoner than we believe, occurring in at least 4.8% of the term placenta,7 it is expected that more ‘false positives’ of NIPT due to CPM will be encountered when the use of NIPT becomes more widespread. This raises a fundamental question of whether amniocentesis is a more appropriate and reliable follow up diagnostic test than CVS in case of positive NIPT, especially if there is absence of sonographic features in the fetus suggestive of trisomy” “In three of the four placenta biopsies, the QF-PCR showed trisomy 21 but karyotyping after long-term culture was normal. This is typical of type 1 CPM,4 in which the trisomic cells are confined to the trophoblasts. This type of CPM is usually considered to be associated with a normal fetal outcome. “ Usually Trisomy 21 has no CPM3.
+18 I have a screen positive NIPT FOR TRISOMY 18 “Edward’s Syndrome”
**WHAT IS THE RISK FOR A TRUE POSITIVE FOR A + SCREEN FROM NIPT FOR TRISOMY 18*\* TLTR: risk is based on age, PPV calculator below, if normal NT scan at 13 weeks, likely a good outcome, wait for amnio if normal sono, CVS is sono is abnormal. Prone to confined placental mosaicm type 1,2 and 3. If you had a positive screen for NIPT for Trisomy 18 there is a positive predictive value calculator to estimate the risk for actual true positive vs a false positive that can be found here: https://www.perinatalquality.org/Vendors/NSGC/NIPT/ The risk of a true positive is directly related to female’s age during pregnancy. These are MUCH LOWER true positives than NIPT screen positive for trisomy 21.
NIPT + for 25 year old has a PPV of 15% (aka it’s a true positive only 15% of the time… false positive rate for 25 year old NIPT positive with t18 is 85%)
30 years old PPV 21% (false positive 79%)
35 years old PPV 40% (false positive 60%)
40 years old PPV 70% (false positive 30%)
NEXT STEP: REQUEST NT SCAN, REFERRAL TO MFM and GENETIC COUNSELOR IMMEDIATELY Trisomy 18 is usually visible by week 13 so during your NT scan abut 93-97% of the time. This makes a normal sono/normal NT scan a very likely case for a false positive. IN THIS CASE DO NOT HAVE A CVS. More info below on that. Blood work for triple screen above, low pappa, low hcg and nigh NT are typical. Sonographic evidence of trisomy 18: Trisomy 18 fetuses can have multiple anomalies in multiple systems. Over 130 features have been reported. Out of the three main trisomies, this trisomy has the highest incidence of major structural anomalies. https://radiopaedia.org/articles/edwards-syndrome-1?lang=us
In trisomy 18 the features may include agenesis of the corpus callosum, meningomyelocele, ventriculomegaly, chorioid plexus cysts, posterior fossa anomalies, cleft lip and palate, micrognathia, low-set ears, microphtalmia, hypertelorism, short radial ray, clenched hands with overriding index fingers, club or rocker bottom feet, omphalocele, diaphragmatic hernia, renal anomalies, cardiac defects, SUA, polyhydramnios, nuchal thickening or hygroma and cryptorchidism https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286865/ Of 98 fetuses with trisomy 18, 95 (97%) were detected sonographically; an anomaly was found in 92 (94%). A biometric measurement below the fifth percentile was noted in 50 (51%). Cardiac (63%) and central nervous system (34%) anomalies were most frequently detected. Although choroid plexus cysts were commonly seen, no fetuses with trisomy 18 and isolated choroid plexus cysts were found.Conclusions.Targeted sonography identified abnormal fetal anatomy or abnormal biometric findings in 97% of fetuses with trisomy 18 in the second trimester. A biometric measurement below the fifth percentile was noted in half of the cases in the second trimester. https://onlinelibrary.wiley.com/doi/full/10.7863/jum.2008.27.7.1033 CONFINED PLACENTAL MOSAICISM IN TRISOMY 18 and NEED FOR AMNIO IN SONOGRAPHICALLY NORMAL FETUSES Trisomy 13 and 18 are prone to something called confined placental mosaicism type 3 which affects all placental layers but does not affect the fetus. So in fact; the CVS can be 100% positive for trisomy 13 and 18 and the actual fetus is not affected. See the above graphic at the beginning. This is one of the reasons I started this sub so that no other person goes wrongful termination or receives proper counseling about this or has seen the data. With a normal sono, it’s absolutely prudent that people are counseled on this scenario so that they can elect an amnio to be absolutely sure. CVS is a great option to confirm sonographic findings as, again, over 95% of trisomy 18 fetuses have visible abnormalities by week 13 with many of the above features. It is absolutely reasonable to get a CVS for confirmation of sonographically abnormal NIPT positive trisomy 18 result. IF NIPT is positive but the sono shows a normal fetus, PAUSE. And do more research, get a really good genetic counselor on board that will recommend an amnio instead. CPM type 3 in trisomy 18 and 13 has extremely good outcomes for live birth and usually doesn’t affect development of the fetus even though all placental cells are abnormal. There is some correlation with IUGR and trisomy 13 in placenta. This is not usually the case for trisomy 21 and CPM1 is more common but CPM3 is extremely rare which is why cvs on t21 nIPT is much more reasonable with the long term culture as the inner layer of the placenta typically matches the fetus. This is not always the case for t13 and t18. Some MFMs will therefore take t21 cvs data and apply it all other chromosomes since other chromosomes are actually rare to see in general, but there are a lot of t21 cases. All these chromosomes are different about how they present, what the differences, how they correct self in fetal development and how CPM can interact with fetal growth or progression. Please also note comments re-CVS and NIPT in the t21 example. You would need multiple placental biopsies to rule one thing or another out, vs taking out an amnio sample is definitive since there should be no abnormal cells shed in to the fluid. Placental biopsies can show completely different results when multiple biopsies taken after birth or post mortem. Examples of this can be provided or will be posted below as well. I truly hope that anyone reading in the future can and does look at the above papers about sonos and t13 and t18 nIPT, understands PPV, understands what cvs can and can’t do, why waiting for amnio may be a better option and understands what their options are. This is also a great example of how ultrasound and NT scan is obviously useful in trisomy 13, 18 presentations. Basically all trisomy 13 cases were seen on NT scan and 2/30 looked normal on NT scan with trisomy 18 but at 18 weeks showed the abnormalities. All false positive cases had normal NT scans and normal anatomy scans. https://obgyn.onlinelibrary.wiley.com/doi/full/10.1002/uog.13388 The role of ultrasound in women with a positive NIPT result for trisomy 18 and 13 https://www.sciencedirect.com/science/article/pii/S1028455919302177 "There were 81 patients with a positive NIPT result for trisomy 18/13, including 39 (30 positive for trisomy 18; 9 positive for trisomy 13) within 12–14 weeks of gestation, and 42 (31 positive for trisomy 18; 11 positive for trisomy 13) within 15–22 weeks. The PPV of NIPT was 60.7% for trisomy 18, and 30% for trisomy 13, respectively. When adding ultrasound to NIPT, the new PPV for trisomy 18 was 100%, and the negative predictive value (NPV) was 92.3%, with a NPV of 85.7% in the first trimester and a NPV of 100% in the second trimester, respectively. The new PPV and NPV for trisomy 13 were 100% and 100%, respectively." Examples of false positive / true positives https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-015-0569-y/tables/1 false positive case study https://journals.lww.com/greenjournal/Abstract/2017/05001/Confined_Placental_Trisomy_18_Mosaicism_Detected.492.aspx In the sub: false positive examples https://www.reddit.com/NIPT/comments/gt544e/little_chulzlette_and_the_reason_i_started_this/ https://www.reddit.com/NIPT/comments/ecl5zq/my_experience_with_a_false_positive_t18_nipt/
+13 I have a screen positive NIPT FOR TRISOMY 13 “Patau Syndrome"
**WHAT IS THE RISK FOR A TRUE POSITIVE FOR A + SCREEN FROM NIPT FOR TRISOMY 13*\* TLTR: risk is based on age and overall true positives are rare, PPV calculator below, if normal NT scan at 13 weeks, likely a good outcome,wait for amnio if normal sono, it is almost certain you are dealing with confined placental mosaicism, CVS if sono is abnormal to confirm. Very visible on NT scans. Prone to confined placental mosaicm type 1 and 3 and CAN be associated with precclampsia or hypertensive disorders of pregnancy. If you had a positive screen for NIPT for Trisomy 13 there is a positive predictive value calculator to estimate the risk for actual true positive vs a false positive that can be found here: https://www.perinatalquality.org/Vendors/NSGC/NIPT/ The risk of a true positive is directly related to female’s age during pregnancy. These are MUCH LOWER true positives than NIPT screen positive for trisomy 21.
NIPT + for 25 year old has a PPV of 7% (aka it’s a true positive only 7% of the time… false positive rate for 25 year old NIPT positive with t18 is 93%)
30 years old PPV 10% (false positive 90%)
35 years old PPV 20% (false positive 80%)
40 years old PPV 50% (false positive 50%)
Bloodwork and NT screen: NT usually enlarged, pappa and HCG are LOW
NEXT STEP: REQUEST NT SCAN, REFERRAL TO MFM and GENETIC COUNSELOR IMMEDIATELY Trisomy 18 is usually visible by week 13 so during your NT scan abut 93-97% of the time. This makes a normal sono/normal NT scan a very likely case for a false positive. IN THIS CASE DO NOT HAVE A CVS. More info below on that. Blood work for triple screen above, low pappa, low hcg and nigh NT are typical. Sonographic evidence of trisomy 13. https://radiopaedia.org/articles/patau-syndrome?lang=us
"Given the unfavorable balance between benefit and harm related to using NIPT to test for T13, we suggest reconsidering its use, especially in a general population. Owing to the issue of confined placental mosaicism, chorionic villus sampling is not recommended. Almost all T13 cases are associated with multiple anomalies that are hard to miss on detailed ultrasound examination. Papageorghiou et al. described that > 90% of T13 cases are identified at the 11–14‐week scan10. In conclusion, screening for diseases that are lethal in the fetal or early neonatal period, at the expense of serious anxiety and iatrogenic miscarriage of healthy fetuses, may do more harm than good. In our view, a patient with a positive NIPT result for T13 and a completely normal detailed ultrasound examination should be reassured that invasive testing is unnecessary." https://obgyn.onlinelibrary.wiley.com/doi/full/10.1002/uog.13388 Highly inaccurate for NIPT as far as fetal involvement.
CPM in trisomy 13 can be associated with hypertensive disorders
We present a case series of six women with a cfDNA results screen positive for trisomy 13, who subsequently were found to have normal karyotypes or normal neonatal outcome. Four out of the five women (80%) for whom delivery information was available went on to develop gestational hypertensive disorders, one of which was severe and required preterm delivery. https://ndownloader.figstatic.com/files/11073932
Note here that there are many cases of of fully abnormal CVS with normal fetuses
2020.09.14 09:46 steven611Samsung Galaxy Repair Washington DC
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2020.08.26 13:50 MrSamurai1998A New Home: A MrSamurai Story
Hello there, fellow Reddit users. Trigger warning: This story involves a lot of narcissistic abuse, references to anger issues and depression, and there will be talks of self harm and suicide. Also, my nDad will be referred to by his first name. So my story began in 1998: I was born. Things were okay until I was about 3-4, when my parents split up. My mum tried to take my brother (younger, he was born before the divorce) and I away from Alan, only to lose us in a custody battle. Since then, my brother (his name is Matt) and I have been stuck with Alan. Things weren't entirely bad as Matt and I both had our grandmother and friends and our mum (to a lesser degree, she was unable to help due to having to deal with a controlling boyfriend, but she gave us emotional support). During my time with Alan, I have been berated, belittled and bullied for little things. Everytime I had a normal reaction to Matt giving me shit (Matt was the golden child, I was the scapegoat), Alan would dismiss it and tell me that I was very sensitive. When an incident occurred in 2015 that lead to my being investigated due to allegedly being at risk of radicalisation (because I had an interest in Islam during the time when ISIS was a thing, which is ironic since I despise terrorists or groups that use religion to justify violence), the only two people in my family who wholeheartedly supported me were my grandmother (Alan's mum) and my mum. Alan, on the other hand, would take whatever lies the social worker said and just eat them up. Granted, only one social worker (out of the three who covered my case) did this: He said that I stated that I was "semi-radicalised", when actually I just said that I semi-converted to Islam, but ended up not going through with it due to Ramadan and the rule that pork was forbidden. The recurring theme in this investigation is that the people "in control" of the investigation like to forget details that challenge (if not utterly destroy) the whole purpose of the investigation: Namely the fact that I despised terrorism or groups that use religion to justify violence: That very fact alone should have been enough to lead to the investigation being thrown out of the window with the parties involved giving me one heck of an apology for the stress and damage to my mental health (this was the only time I committed self-harm and perhaps the first time I actually seriously contemplated suicide) that this whole debacle has caused. Fast-forward a year later: I get a job at Sainsburys, thanks to the Sixth Form's work experience program. Alan was the only member of my family who was unsupportive of it, stating that it will be a pain in the ass (he said this to me on my first actual shift) and expecting me to put extracurriculars (like archery, which I actually ended up hating due to being forced to attend) before work. But he liked the money that came out of it (this is important later). Throughout the next few years, Alan will browbeat me about anything (weight, my alleged lacking of a social life, little things that bother him), and if I dared to snap back at him, he'd say "I can kick you out, you know", and that was something I avoided because I was neither financially ready or mature enough to strike it out on my own. Matt started to open his eyes around that time, being the first out of the two of us to spot Alan's narcissism and decide "Well, I'm gonna go NC as soon as I move out. He's had way too many chances". Things did get interesting especially in 2019: Earlier in the year, Alan told me just as he was cutting my hair (he didn't mind cutting my hair for free) that I was an accident. But he didn't say it out of anger or frustration. He just said it in the same manner as one would when telling someone an interesting fact. I wasn't hurt by this, but that was at the back of my mind. Fast-forward to November of that year: Alan calls me and Matt down early in the morning and tells us of his plans to move to Thailand. See, he got rejected by a girl at work and therefore took it as a sign that he had done nothing with his 50+ years on Earth because, and get this: His reasoning for why he did nothing with his life was because he was held back by Matt and I, my mum and my grandmother (his mum, who passed away back in November). On it's own, it's bad enough. But with the earlier revelation in the back of my mind, it confirmed one thing: Alan fucking resented the fact that he was a father and had responsibilities to uphold. A week later, he fucked off to Athens (where my uncle and aunt (his brother and sister-in-law) live) for a week, intending on staying if he got a job over there. During the week when he was gone, I started to heal a little bit and then I realised that I needed to leave within the next year or two if I want to heal. So within the next few months, I started making moves to get myself out of there. I got into contact with a rental agency in Plymouth (the same guys who a classmate at uni recommended) and viewed an apartment over there. This was at the same time when Alan started trying to charge me rent (even when faced with the fact that he did very little whatsoever to be supportive of the fact that I had a job, which he still refused to apologise for). So, on February 15th, I decided that enough was enough. I contacted a friend of mine and asked if I could stay with him until I move to Plymouth. I moved to Babbacombe (about 30 mins away from Alan's place) and stayed there with a friend of mine. Of course, that came with it's own set of issues: My friend, Alex: He had autism, PDA, anxiety and depression. He would smash up anything nearby when he was angry (which was pretty often). And this was before everything kicked off with COVID-19. In fact, after my last visit to my university before it closed due to lockdown, I heard that Alex lost it and started smashing stuff up (destroying his iPad and damaging the ceiling of the flat below). It all continued to get worse and worse: Alex lost his job due to him cussing out management and customers since the latter refused to adhere to social distancing (he ended up destroying his bedroom door); Everytime something happened between him and his girlfriend, he would smash up the flat and scream at his girlfriend to "be compliant" since he would want her to retract a statement or delete a message that even used death or killing as a metaphor. Most times, Andy (his dad: Someone who I respect immensely. He's the father I never had) would head over and try and calm down the situation. Of course, Alex would bring his fury towards him, yelling at him. It once got to the point where Alex lashed out verbally at me, smashed up his flat and even threw Andy into the couch, all because his girlfriend wanted to head outside for a bit and he didn't like that. I ended up realising that I could not survive in this environment, so I contacted the rental agency to move in earlier and I spoke to Andy about my decision to move out in August (I was originally going to move in September, but that was because I thought I could live in this environment until then). Of course, Alex would continuously get worse and worse. And his girlfriend would continue to defend him. You see, his girlfriend is very inconsistent with him: She would berate him for the smallest of things, and yet blame everyone around him but him when it comes to major things (even once blaming me for telling Alex that his anger issues are bad for my mental health). Heck, it even got to the point where I had to call the police on him due to the fact that I felt unsafe being in the same building as him when he was like this (he got very angry when Andy set the vacuum cleaner onto the floor to look at it since it was broken). Suffice to say, I'm in Plymouth now. I've been living here for nearly 2 weeks. I'm mostly healed, I'm getting there. Alan wrote me out of his will after I moved out. Not that I care, I'm working two part-time jobs (one until December this year with a payout of £1920; the other is a regular retail job that pays me at least £446.60 a month), and I'm getting maintenance loans due to my studying at university, I think I'll be loaded by the end of the year. Do I wish that I had to go through all that? No, nobody should have to go through all that. I'm not writing this to say to people "Hey, I found success, I can do it. Use me as inspiration". If I do inspire people, then cool. But, I am only writing this purely because this is a story that I want to tell.
2020.08.10 07:12 realmobile21Samsung Galaxy Repair Washington DC
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2020.08.06 10:44 realmobile21Samsung Galaxy Repair Washington DC
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2020.08.04 19:51 MumSageOnly had 15 months with them
I've been lurking and commenting in this sub for the past week or so--the perspective & compassion here have been truly helpful. I've been trying to pull together my thoughts to write a post but there feels like so much to say. And yet I only knew my partner (nonbinary, answered to any pronoun--here I'll use "he") for 15 months. In that time, we created a whole new language of in-jokes. We clicked from the start--compatible intellectually, emotionally, physically. By May 2019 I returned his "I love you" (after thinking about it--he told me later how much he loved that I weighed and considered my feelings before saying so). He was the first person I was ever so comfortable with that I could just fall asleep beside him, or work with him in the next room. We talked about buying a house together. The last time we saw each other in person I told him I intended to have him in my life forever. He said meeting me was like "opening up a forgotten door in my house to find entire wings, whole corridors and lofty halls I never suspected were there." It was the same for me. I had gone on the online dating site expecting to find something short-term or maybe just friendship--I wound up with someone I would unabashedly call a soulmate. But he died unexpectedly, for reasons we're still not certain of, about 15 months to the day I first started messaging him about books we liked. From posts on this site I know if I'd known him for decades the pain of losing him would be no less--it might even be more staggering. And we couldn't possibly have loved each other more than we already did in any amount of time. We never passed up the chance to compliment each other, support each other, or hold each other (yes, we were *that* PDA couple). But I wish so much that our happiness could have lasted longer. He had some struggles in life with anxiety, trauma, and probably depression. He was able to start addressing them but I wish he could have made more progress. He deserved that time and more happiness. He had so much to live for and so much he looked forward to, including seeing me again. I take some comfort from the fact that he had hope in the future. But I also have these waves of anger at how unfair it is that I couldn't have had him in my life longer, as more than a sweet memory. He always wanted to find ways to make me happier and my life easier. One thing I know he'd be proud of is that, after being as happy with him as I was, I'm never going to settle for less. We'd talked about prior relationships we had where we compromised too much of who we were (and we were grade-A weirdos and proud of it) and knew it would never happen again. But I'm certainly not ready to move on yet. And I have to admit, I'm scared of what it's going to be like when he's been gone for 16 months--when I've been mourning him for longer than I was ever with him. I don't know if this is really the kind of thing anybody can give advice on, but I'd love to hear from anyone who went through something similar--or even very different. https://preview.redd.it/u3dpi5sex0f51.jpg?width=2448&format=pjpg&auto=webp&s=7790de3f5633ff7fa8c24c529117b6e95aaa4c1e
I've been lurking and commenting in this sub for the past week or so--the perspective & compassion here have been truly helpful. I've been trying to pull together my thoughts to write a post but there feels like so much to say. And yet I only knew my partner for 15 months. In that time, we created a whole new language of in-jokes. We clicked from the start--compatible intellectually, emotionally, physically. By May 2019 I returned his "I love you" (after thinking about it--he told me later how much he loved that I weighed and considered my feelings before saying so). He was the first partner I was ever so comfortable with that I could just fall asleep beside him, or work with him in the next room. We talked about buying a house together. The last time we saw each other in person I told him I intended to have him in my life forever. He said meeting me was like "opening up a forgotten door in my house to find entire wings, whole corridors and lofty halls I never suspected were there." It was the same for me. I had gone on the online dating site expecting to find something short-term or maybe just friendship--I wound up with someone I would unabashedly call a soulmate. But he died unexpectedly, for reasons we're still not certain of, about 15 months to the day I first started messaging him about books we liked. From posts on this site I know if I'd known him for decades the pain of losing him would be no less--it might even be more staggering. And we couldn't possibly have loved each other more than we already did in any amount of time. We never passed up the chance to compliment each other, support each other, or hold each other (yes, we were *that* PDA couple). But I wish so much that our happiness could have lasted longer. He had some struggles in life with anxiety, trauma, and probably depression. He was able to start addressing them but I wish he could have made more progress. He deserved that time and more happiness. He had so much to live for and so much he looked forward to, including seeing me again. I take some comfort from the fact that he had hope in the future. But I also have these waves of anger at how unfair it is that I couldn't have had him in my life longer, as more than a sweet memory. He always wanted to find ways to make me happier and my life easier. One thing I know he'd be proud of is that, after being as happy with him as I was, I'm never going to settle for less. We'd talked about prior relationships we had where we compromised too much of who we were (and we were grade-A weirdos and proud of it) and knew it would never happen again. But I'm certainly not ready to move on yet. And I have to admit, I'm scared of what it's going to be like when he's been gone for 16 months--when I've been mourning him for longer than I was ever with him. I don't know if this is really the kind of thing anybody can give advice on, but I'd love to hear from anyone who went through something similar--or very different. https://preview.redd.it/r20z1sm7p0f51.jpg?width=2448&format=pjpg&auto=webp&s=8faf72e9839bb026e657c2edcc490f63cf5ea0cf
2020.08.01 08:47 A1cheezeI don't know if Im an efficient partner
I guess to start this off I should give some background. I am a man (24M), and I have two X chromosomes (XXY) I don't know if this issue is because of my syndrome or not. Or if anyone else deals with this. By the way the only thing I really have from the syndrome is my height (maybe) my parents are tall, small testes, and I'm pretty thin. I had a pretty strict upbringing, 3 parents (my mother and father split). My mother was a die hard christian, my father a strict Catholic. Sex before marriage was looked down on, but when I was younger I wasn't even worried about sex because from what my friends at the time told me about it, I was a little too inadequate. I wasn't even really exposed to porn until I came back from overseas. I didn't start dating until I joined the military, and went overseas to Germany. I like so many young people, flocked to tinder, and I met within my first week there, my first partner. We talked maybe a month before we met up for a date. When we dated I felt very awkward with PDA, mainly because I had no idea what I was doing. We were never sexually active, because with my condition, I hadn't even had the urge for it. Our relationship was really just going on dates, which to be 💯 wasn't bad. That relationship unfortunately ended due to work getting increasingly more difficult. After her I saw a woman for about a month. That was also an awesome time for me because it was just dates and hanging out. Even when we slept together for the first time it was clothes on, and we just chilled and talked and cuddled. And after that first time she thanked me for not taking it further, but in the back of my head I didn't even comprehend it like that because I just felt lucky to be there. I guess honestly would be the best policy here so the only time I ever had sex there, was in a brothel and I didn't really even do anything because i didn't know what to do. See a friend and I went to a brothel before that one, and I couldn't even "perform" there. I felt so awkward and out of place. I didn't know this woman, and I didn't have any practice to speak of. So we left, and we went to a strip club. And there I got my mind in order. We went out a different one and I had to psyche myself into it. I told her it was my first time, and asked if we could go slow. I laid there at first and then she encouraged me to start doing other stuff. But the thing was I couldn't feel anything. I'm not saying emotionally, but physically. All I felt was warmth. I spent an hour with her, doing all kinds of things and I could see she was getting frustrated, so I faked an orgasm, and thanked her. And I didn't think anything of it. After I finished my service, I came back home, and after I settled into my life in the states I started looking to date again. I had gotten matches here and there, nothing major. In February of 2019, I met my ex. Right off the bat it was incredible. The dating was awesome, She was and is incredibly gifted, artistically and intellectually. But the sexual experience was amazing as well. She didn't open my mind to alot of anything, more so she allowed me to explore her body and that opened my mind to things. But the first time we had sex, I went for about two hours, before she was done. Nothing. At this point this had happened twice, and It couldn't have been a coincidence. I let her know what had happened and when we had sex again after a few days the same thing happened. This really affected her mood. I tried to tell her it was my body, but I could see the visible disappointment. She tried to do different things all over the vanilla spectrum of what could be done, but to no avail. I was active in the action of sex though. I was just laying there, I did what she liked, whether that was SFW or NSFW, I just didn't get anything on my end. But knowing that she was satisfied was good enough for the most part. That being said to this day I've never had an orgasm with a partner. But outside of all the Sexual stuff I enjoy doing everything else that dating is. Sex isn't a huge part of dating, especially not for me, but it is important. I want to know if I can be an efficient partner even though that aspect of the relationship will be one sided. I know that type of thing can wear down on the relationship between two people but I don't know if my issue will hinder me from having a full and rich relationship, Not just for me but for my partner. Because I'm not asexual, I like having sex, I love the way our bodies move and contort, and the energy that's shared. I just worry that that sort of thing might be in the back of my partners mind, or that they're doing something wrong despite me saying it's me, or that I'm not into it, or whatever. With all of that being I wanted to know, If, When and How I should bring that up with future partners? Is there anything I can do to maybe fix what's going on? And Can I have a healthy one-sided relationship?
2020.07.28 21:55 A1cheezeI don't know if I'm an efficient partner
I guess to start this off I should give some background. I am a man (24M), and I have two X chromosomes (XXY) I don't know if this issue is because of my syndrome or not. Or if anyone else deals with this. By the way the only thing I really have from the syndrome is my height (maybe) my parents are tall, small testes, and I'm pretty thin. I had a pretty strict upbringing, 3 parents (my mother and father split). My mother was a die hard christian, my father a strict Catholic. Sex before marriage was looked down on, but when I was younger I wasn't even worried about sex because from what my friends at the time told me about it, I was a little too inadequate. I wasn't even really exposed to porn until I came back from overseas. I didn't start dating until I joined the military, and went overseas to Germany. I like so many young people, flocked to tinder, and I met within my first week there, my first partner. We talked maybe a month before we met up for a date. When we dated I felt very awkward with PDA, mainly because I had no idea what I was doing. We were never sexually active, because with my condition, I hadn't even had the urge for it. Our relationship was really just going on dates, which to be 💯 wasn't bad. That relationship unfortunately ended due to work getting increasingly more difficult. After her I saw a woman for about a month. That was also an awesome time for me because it was just dates and hanging out. Even when we slept together for the first time it was clothes on, and we just chilled and talked and cuddled. And after that first time she thanked me for not taking it further, but in the back of my head I didn't even comprehend it like that because I just felt lucky to be there. I guess honestly would be the best policy here so the only time I ever had sex there, was in a brothel and I didn't really even do anything because i didn't know what to do. See a friend and I went to a brothel before that one, and I couldn't even "perform" there. I felt so awkward and out of place. I didn't know this woman, and I didn't have any practice to speak of. So we left, and we went to a strip club. And there I got my mind in order. We went out a different one and I had to psyche myself into it. I told her it was my first time, and asked if we could go slow. I laid there at first and then she encouraged me to start doing other stuff. But the thing was I couldn't feel anything. I'm not saying emotionally, but physically. All I felt was warmth. I spent an hour with her, doing all kinds of things and I could see she was getting frustrated, so I faked an orgasm, and thanked her. And I didn't think anything of it. After I finished my service, I came back home, and after I settled into my life in the states I started looking to date again. I had gotten matches here and there, nothing major. In February of 2019, I met my ex. Right off the bat it was incredible. The dating was awesome, She was and is incredibly gifted, artistically and intellectually. But the sexual experience was amazing as well. She didn't open my mind to alot of anything, more so she allowed me to explore her body and that opened my mind to things. But the first time we had sex, I went for about two hours, before she was done. Nothing. At this point this had happened twice, and It couldn't have been a coincidence. I let her know what had happened and when we had sex again after a few days the same thing happened. This really affected her mood. I tried to tell her it was my body, but I could see the visible disappointment. She tried to do different things all over the vanilla spectrum of what could be done, but to no avail. I was active in the action of sex though. I was just laying there, I did what she liked, whether that was SFW or NSFW, I just didn't get anything on my end. But knowing that she was satisfied was good enough for the most part. That being said to this day I've never had an orgasm with a partner. But outside of all the Sexual stuff I enjoy doing everything else that dating is. Sex isn't a huge part of dating, especially not for me, but it is important. I want to know if I can be an efficient partner even though that aspect of the relationship will be one sided. I know that type of thing can wear down on the relationship between two people but I don't know if my issue will hinder me from having a full and rich relationship, Not just for me but for my partner. Because I'm not asexual, I like having sex, I love the way our bodies move and contort, and the energy that's shared. I just worry that that sort of thing might be in the back of my partners mind, or that they're doing something wrong despite me saying it's me, or that I'm not into it, or whatever. In that aspect, I don't know if im efficient enough and I would love to hear other people's opinions.
2020.07.23 12:24 Mimetic_Alpha 12.3 Public Release 23/07/2020
Hi Galactic Survivalists! Today we are releasing Alpha 12.3. This will be the last 12.x version before we are leaving Early Access on 5th of august. Please read the sticky dev blog announcements over here for more info on that topic: https://empyriononline.com/forums/news-announcements.6/ Alpha 12.3 not only adds new content, like new drone models, new NPCs, turrets and T2 laser drills for Small Vessels and such. The new version also upgrades the game to Unity 2019.4, which means a lot of backend work had to happen in the meantime. Of course the update includes several bug fixes, as well as optimizations and adjustments - for example on the Space AI. When a NPC drone, ship or station spot's you, they will send the information to the whole faction in the system, and the faction may send some ships from the system to deal with the threat. For new and experienced players alike, the difficulty settings now define, if you will keep all your stuff (Easy), toolbar contents only (Medium) or everything drops as before (Hard) when you respawn after death. We also added a dynamic warp sequence instead of the old loading screen. And in case you need to have a rest from all the exploring, simply sit down at any bench, chair, sofa or other suitable furnishings. As usual:
Hello Galactic Survivalists! Here is the EXP version for the upcoming Alpha 12.3 patch. Please test as much as you like and give us feedback - thanks a lot!! 2020-07-22 Patch 12.3 (Build 2995) Changes:
sending package global player info also on low prio channel now
moved some packages (chat, DB data, pinginfo) to low prio channel and also decreased ping info package frequency to 20s (old: 5s)
adjusted channel priorities for less disconnects on heavy traffic servers
Space AI Manager update: temporarily added debug UI to release build, fixed velocity prediction, added debug display for search range
Added icon for SV turret
Added template and techtree entry for SV turret
Added destroyed models for Trader and Polaris space drones
Added Legacy space drone (no destroyed model yet)
SV Laser Drill now allowed in space and on planets
Added two versions of 'battered' Space Drone Laser for Civilian Faction (Not yet added to playfields)
07385: Logi network range with or without Wireless device has wrong ranges
Reactivated Robinson Protocol for 12.3 release (Default Random Scenario; Plz give a quick try)
Fixed bug that Station Interface was not considering a general discount for repair
Disconnect improvements: EAC packages are now sent with high priority
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Ltd. It was made on 24th April 1981. Hong Realty (Private) Limited (HRPL) is a right hand of Hong Leong Investment Pte. Ltd. It was taken a gander at 1962. HRPL is under Hong Leong Group who is one of Asia's usually discernable and best wholes with more than 40,000 staffs all around. Hong Leong Group is extraordinary stood separated from other property facilitator in Singapore. with asset more than S$40 billion. The Group has developed more than 130 premiums private undertakings and more than 100 quality business and mixed use degrees of progress in Singapore. Hong Leong Group is the pioneer fashioner what's judiciously a huge executive and landowner in Singapore. Midtown Modern will be their immense level extravagance obligation with the Prime District 7 Midtown Modern space suite concerning is yet to be tended to. Zone Midtown Modern Location is unmistakably the imperativeness of the undertaking. It is reliably joined to the Bugis MRT station (EW12/DT14), and will have underground individual by walking interface from Midtown Modern to Guoco Midtown on Beach Road, With this recognizable space, in Prime District 7 of Singapore, Midtown Modern is an especially filtered for in the wake of undertaking for investigators and property holders. Bugis contains a stunning mix of clarifications and heritage parts. With its region to the CBD zone, it is 10 minutes' walk around Esplanade MRT station (CC3) and 12 minutes' walk around City Hall MRT Interchange (NS25/EW13). Bugis MRT is a trade for 2 lines, East-West Line and Downtown Line that interfaces you to all bits of Singapore with no issue. Midtown Modern is at the clarification behind mixing of Singapore. For drivers, you can pick East Coast Parkway (ECP), Marina Costal Expressway (MCE), Ayer Rajah Expressway (AYE) and Central Expressway (CTE). The standard North-South piece (NSC) will be in association this year. It joins Northern bits of Singapore and East Coast Park together. One of its scratching wire is to join transport ways and cycling ways together. For watches looking at for basic and assistant schools around Midtown Modern, we can consider Stamford Primary School, Farrer Park Primary, St. Margaret's Primary School and Outram Secondary School of The Arts. Concerning, schools and private instituition, there is Insworld Institute, Singapore Management University, Dimensions, Nanyang Academy of Fine Arts, Kaplan and other stunning watches. To discover all the all the all the all the all the all the all the additionally including civilities, you can investigate our Midtown Modern space map. Showflat To book a Midtown Modern Showflat approach, generally register through this authority fashioner site or you can call our methodology hotline really at +65 6100 9266 going before flooding toward the show level. Our Midtown Modern showroom might be closed pondering routine upkeep, or shut to individuals if all else fails by tolerability of organizers' private events. In like way all visitors are imaginatively gotten a couple of information about a showflat procedure before going down to our showroom to bewilder any heaps caused Each and every contributed person who had held a showroom meeting with us through this official way, if its jumbled to you have request that our central will interface with you by approachs for your PDA inside an hour, or the following day if it is after the authority showflat closing hour. Rest ensure that you are have the choice to abuse our possible Direct Developer Price with NO COMMISSION payable by buyer. We are at present in the early phase of Registration of Interest for Midtown Modern VVIP Preview. Register your Interest totally on an ideal opportunity to be the first to see our confounding Showflat once its readied for graph. We will reestablish Midtown Modern Balance Units Chart and Midtown Modern Pricing in this official site once the undertaking is impelled. Generously note that all correspondence units open to be bought at Midtown Modern Condo rely on from the most punctual beginning stage things out serve premise. We do allow reservation of unit up to 2 hours and it is spun around the specialists' ensuring. Cost passed on around there ponders change with no further notification. Cautiously don't miss this confusing new townhouse suite dispatch @ Bugis MRT by Guocoland, Intrepid Investments and Hong Realty. Only 580 select units are open. Register now for Midtown Modern VVIP Preview today. About Midtown Modern Midtown [email protected] Tan Quee Lan Street is the latest endeavor by Guocoland and Hong Leong. Isolated through on the most significant degree of the city and close Bugis MRT Interchange Station (EW12/DT14), plans high straightforwardness all through Singapore. Urban Redevelopment Authority (URA) released a touchy for a 99-year leasehold site under the Government Land Sales Program in 29 March 2019. The site, which has a land zone of 11,530.9 Sqm with net floor area (GFA)of 48,430 Sqm, proposed to make around 580 units. The questionable was won by the joint undertaking of GLL D Pte. Ltd. (GLL D), Intrepid Investments Pte. Ltd. (Strong) and Hong Realty (Private) Limited. (HRPL) at $800.19million in September 2019. Midtown Modern will be the last piece of jigsaw puzzle that completes the limit in the Beach Road zone. Tiong Seng Holdings is named to make Midtown Modern. There will be 2 structures of 30 Story with business retail shops at 1st story. Near the retails space, Midtown Modern will in like way have an open court, a vehicle leave, an underground walker interface and shared workplaces, for instance, a pool, scene deck, practice room and a notoriety clubhouse. Bugis zone is accumulated with verbalizations, culture and heritage. We can visit National Museum of Singapore, Mint Museum of Toys, Singapore Art Museum, National Museum and National Library. For schools contemplations around Midtown Modern loft suite, we can consider Stamford Primary School, Farrer Park Primary, St. Margaret's Primary School and Outram Secondary School of The Arts, Insworld Institute, Singapore Management University, Dimensions, Laselle College of the Arts, Nanyang Academy of Fine Arts, Kaplan and other telecom takes vibe. For extra cordialities, we can discover in Midtown Modern Location Map. Midtown Modern is region to the near current strip malls, for instance, Suntec City, Bugis Junction, and Bugis+, Duo Galleria, Esplanade and Raffles City Shopping Center and The Cathay. It can set you up a red hot life there with an enormous level of updates and eating decisions. Eminent bistros and earth shattering pieces of clothing brands draws you each second of thought. In case you have to shop outside, Bugis Street Market offers a wide strategy of sensible and standard at any rate clear things which overwhelm you with smiles. Best among of for cash related chief, Midtown Modern Singapore is melded by not 1 yet rather 6 Grade-A work environments. They are Shaw Towers, Duo Tower, South Beach Tower, Bugis Junction Tower, Parkview Square, and the future Guoco Midtown. Midtown Modern will be associated with the dynamic quality, solace and flooding working conditions of Guoco Midtown. Midtown Modern inhabitants will progress toward a wide level of work environments, affiliations and activities, including a first of its sort business and social club @ Midtown Hub. If you are looking at for uncommon zone with magnificent structure and vivacious lifestyles at the motivation driving party of the City for own remain or hypotheses, Midtown Modern Singapore is in a general sense perfect for you. Each and every contributed individual can download FREE Midtown Modern E-Brochure and Midtown Modern Floor Plan here.
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